OK so ran the full update/immunize/scan using S&D 2.8, it found one issue with a browser BHO. Re-opened JD2 et voila - it is now accessing the update site and updating. The only extensions which seem to have been removed from Google Chrome are :-
Tampermonkey
I Don't care about cookies
I reinstalled both, so will report back here if one/both of these are to blame when next updates to JD2 are due.
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